Do I Need to Take Malaria Pills or Get Certain Vaccinations for my trip to Guatemala?
No vaccinations are officially required to enter Guatemala. That said, it’s a good idea to be up-to-date on typhoid, rabies, yellow fever, measles-mumps-rubella (MMR), and tetanus shots. Getting the hepatitis vaccine also makes sense. If you’ll be visiting rural lowland areas you might want to take malaria pills — you’ll need to begin taking these a few weeks before being potentially exposed to the disease.

Health conditions and vaccination recommendations do change, however, so it’s best to check with your doctor for current requirements before traveling.
Related Questions
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It's more than just having a good time or visiting beautiful places (although that's absolutely a part of it!), it's about being part of a unique experience that stays with you.