For those traveling from other parts of Ecuador, the road conditions to Isabela can be challenging. The island is connected to the mainland by a series of ferries and roads, which can be rough and unpaved in some areas. Travelers should be prepared for a long and potentially bumpy ride, especially during the rainy season.

Once in Isabela, travelers have the option to rent a car or book a private transfer service to get around the island. Renting a car provides the freedom to explore at one's own pace, but it also comes with the responsibility of navigating unfamiliar roads and dealing with potential car troubles. On the other hand, private transfer services offer a hassle-free experience, with drivers familiar with the roads and local conditions. In terms of safety, both options are generally secure, but travelers should exercise caution when driving at night or in remote areas.

Regardless of which option is chosen, travelers are advised to book transportation services in advance, especially during peak season. Isabela is a small island with limited infrastructure, and transportation services can quickly fill up. Booking ahead of time ensures that travelers can secure the services they need, avoiding last-minute stress and inconvenience. Additionally, pre-booking transportation services can also help to streamline the journey, saving time and effort upon arrival.